Understanding taurine CNS activity using alternative zebrafish models (vol 83, pg 525, 2018)

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:90

Correction

Mezzomo, Nathana J.^1,3  Fontana, Barbara D.^1,2  Kalueff, Allan V.^{4,5,6,7,8,9,10,11}  Barcellos, Leonardo J. G.^3,12  Rosemberg, Denis B.^1,2 

[1] Univ Fed Santa Maria, Nat & Exact Sci Ctr, Dept Biochem & Mol Biol, Lab Expt Neuropsychobiol, 1000 Roraima Ave, BR-97105900 Santa Maria, RS, Brazil

[2] Univ Fed Santa Maria, Grad Program Biol Sci Toxicol Biochem, 1000 Roraima Ave, BR-97105900 Santa Maria, RS, Brazil

[3] Univ Fed Santa Maria, Grad Program Pharmacol, 1000 Roraima Ave, BR-97105900 Santa Maria, RS, Brazil

[4] Southwest Univ, Sch Pharm, Chongqing, Peoples R China

[5] Sci Res Inst Physiol & Basic Med, Novosibirsk, Russia

[6] Int Zebrafish Neurosci Res Consortium ZNRC, Slidell, LA USA

[7] Ural Fed Univ, Ekaterinburg, Russia

[8] ZENEREI Res Ctr, Slidell, LA USA

[9] St Petersburg State Univ, Inst Translat Biomed, St Petersburg, Russia

[10] Almazov Natl Med Res Ctr, Inst Expt Med, St Petersburg, Russia

[11] Russian Natl Ctr Radiol & Surg Technol, St Petersburg, Russia

[12] Univ Passo Fundo, Grad Program Bioexperimentat, BR 285, BR-99052900 Passo Fundo, RS, Brazil

关键词: Taurine;    Zebrafish;    Neural function;    Neuropsychopharmacology;    Brain disorder;   

DOI  :  10.1016/j.neubiorev.2018.04.012

来源: Elsevier

【 摘 要 】

Taurine is a highly abundant amino acid in the brain. Although the potential neuroactive role of taurine in vertebrates has long been recognized, the underlying molecular mechanisms related to its pleiotropic effects in the brain remain poorly understood. Due to the genetic tractability, rich behavioral repertoire, neurochemical conservation, and small size, the zebrafish (Danio rerio) has emerged as a powerful candidate for neuropsychopharmacology investigation and in vivo drug screening. Here, we summarize the main physiological roles of taurine in mammals, including neuromodulation, osmoregulation, membrane stabilization, and antioxidant action. In this context, we also highlight how zebrafish models of brain disorders may present interesting approaches to assess molecular mechanisms underlying positive effects of taurine in the brain. Finally, we outline recent advances in zebrafish drug screening that significantly improve neuropsychiatric translational research and small molecule screens.

【 授权许可】

Free