Effects of EGCG and Chlorpyrifos on the Mortality, AChE and GSH of Adult Zebrafish: Independent and Combination

5th Annual International Conference on Material Science and Environmental Engineering

材料科学;生态环境科学

Zhang, Rong^1 ; Zhang, Jian^1 ; Gao, Qian^1 ; Guo, Nichun^1

School of Resources and Environment, Anhui Agricultural University, No. 130, Changjiang West Road, Hefei

230036, China^1

关键词: Acetylcholinesterase;    Chlorpyrifos;    EGCG;    Glutathiones;    Gradual changes;    Zebrafish;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/301/1/012168/pdf
DOI  :  10.1088/1757-899X/301/1/012168

来源: IOP

【 摘 要 】

Chlorpyrifos is a neurotoxic agent and also causes oxidative stress in the body. EGCG is a typical strong antioxidant and has been reported to be neuroprotective. Our study investigated the mortality, the activity of acetylcholinesterase (AChE) in the brain and glutathione (GSH) in the liver of the adult Zebrafish in present of Chlorpyrifos and EGCG independent and combination. The results indicated that after the addition of EGCG, the mortality of zebrafish induced by Chlorpyrifos was reduced and the activity of AChE and glutathione (GSH) inhibited by Chlorpyrifos in zebrafish was significantly increased, which demonstrated that EGCG inhibited the toxicity Chlorpyrifos to zebrafish. The inhibition was dependent on the concentration of EGCG and Chlorpyrifos, which was not shown a gradual change trend but a complex situation.