Adolescent brain development and depression: A case for the importance of connectivity of the anterior cingulate cortex

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:70

Review

Lichenstein, Sarah D.^1,4  Verstynen, Timothy^4,5  Forbes, Erika E.^1,2,3,4 

[1] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Dept Psychiat, 3811 Ohara St, Pittsburgh, PA 15213 USA

[3] Univ Pittsburgh, Dept Pediat, Pittsburgh, PA 15213 USA

[4] Ctr Neural Bases Cognit, Pittsburgh, PA 15213 USA

[5] Carnegie Mellon Univ, Dept Psychol, Pittsburgh, PA 15213 USA

关键词: Adolescence;    Anterior cingulate cortex;    Connectivity;    Development;    Affect regulation;    Depression;   

DOI  :  10.1016/j.neubiorev.2016.07.024

来源: Elsevier

【 摘 要 】

We propose that structural and functional connectivity of the anterior cingulate cortex (ACC) represents a critical component of adolescent developmental psychopathology. We hypothesize that connectivity of the ACC, a hub for integrating cognitive, affective, and social information to guide self-regulation across domains, supports adaptive development of self-regulation during adolescence and that, conversely, disrupted maturation of ACC connectivity contributes to the development of depression. To integrate findings on typical development, we report results of a meta-analysis of diffusion imaging, findings of typical adolescent development of the cingulum and anterior thalamic radiations, the tracts most relevant to ACC connectivity, and provide a critical review of the literature on ACC functional connectivity. Finally, we review the evidence for altered structural and functional connectivity in adolescents with depression. Although the evidence for our claim is persuasive, a more comprehensive understanding of the ACC's role depends upon future investigations with sophisticated modeling of networks, prospective and longitudinal designs, and examination of structure-function associations. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free