Altered Resting State Functional Connectivity of Anterior Cingulate Cortex and Executive Dysfunction in Obsessive-Compulsive Disorder

Anterior cingulate cortex;resting state functional connectivity;functional magnetic resonance imaging;obsessive-compulsive disorder;executive dysfunction;610

의과대학 의학과 ;

University:서울대학교 대학원

关键词: Anterior cingulate cortex;    resting state functional connectivity;    functional magnetic resonance imaging;    obsessive-compulsive disorder;    executive dysfunction;    610;   

Others  :  http://s-space.snu.ac.kr/bitstream/10371/132500/1/000000002701.pdf

美国|英语

来源: Seoul National University Open Repository

【 摘 要 】

Introduction: The anterior cingulate cortex (ACC) is one of the prefrontal targets of the cortico-striato-thalamo-cortical (CSTC) loops in obsessive-compulsive disorder (OCD) and has been regarded as a neural correlate of executive dysfunction. We investigated the resting state functional connectivity networks (rs-FCNs) of ACC functional subdivisions with the aim of clarifying the relationship between rs-FCN derangements and executive dysfunction in patients with OCDMethods: Twenty-one patients with OCD were recruited from Seoul National University Hospital and 22 healthy volunteers (HC) underwent a resting state functional magnetic resonance imaging (fMRI) scan. The rs-FCN maps were depicted using five region-of-interest (ROI) seed regions systemically placed throughout the ACC. Correlations between the five neuropsychological test performances and the regional ACC seed-based rs-FCNs with significantly altered functional connectivity strength were examined in between-group analyses.Results: The rs-FCNs showed rostral/caudal functional distinction in both groups. Between-group analyses revealed significantly weaker functional connectivity of the OCD group in the claustrum, thalamus, and inferior parietal lobule (IPL). Stronger rs-FC between ACC Seed S5 and the right claustrum correlated with higher Rey–Osterrieth Complex Figure Test organization scores. The prolonged Trail Making Test part-A reaction time demonstrated a correlation with weaker rs-FC strength between ACC Seed S7 and the right IPL.Conclusion: Altered strengths in the functional connectivity between ACC seeds versus specific brain areas of the CSTC loop may be the neural correlates of executive dysfunction in OCD. Additionally, the inferior parietal lobule could be one of the important brain regions included in the OCD pathophysiologic loops.