Decreased Intrinsic Functional Connectivity of the Salience Network in Drug-Naïve Patients With Obsessive-Compulsive Disorder

Frontiers in Neuroscience

Qiang Hu¹  Su-Fang Li²  Xiao-Ping Wang³  Yu-Hua Wang⁴  Ping Li⁴  Yun-Hui Chen⁴  Liang-Tang Zhang⁴  Dan Lv⁴  Xiang-Ping Chu⁴  Cheng-Chong Li⁴  Xin Meng⁵  Gui-Dong Zhu⁶ 

[1] Department of Clinical Psychology, Qiqihar Mental Health Center, Qiqihar, China;Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States;Department of Psychiatry, National Clinical Research Center on Mental Disorders, National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China;Department of Psychiatry, Qiqihar Medical University, Qiqihar, China;Department of Radiology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, China;Lishui Second People’s Hospital, Lishui, China;

关键词: obsessive-compulsive disorder;    salience network;    resting-state;    functional magnetic resonance imaging;    intrinsic functional connectivity;   

DOI  :  10.3389/fnins.2018.00889

来源: DOAJ

【 摘 要 】

Obsessive-compulsive disorder (OCD) patients have difficulty in switching between obsessive thought and compulsive behavior, which may be related to the dysfunction of the salience network (SN). However, little is known about the changes in intra- and inter- intrinsic functional connectivity (iFC) of the SN in patients with OCD. In this study, we parceled the SN into 19 subregions and investigated iFC changes for each of these subregions in 40 drug-naïve patients with OCD and 40 healthy controls (HCs) using seed-based functional connectivity resting-state functional magnetic resonance imaging (rs-fMRI). We found that patients with OCD exhibited decreased iFC strength between subregions of the SN, as well as decreased inter-network connectivity between SN and DMN, and ECN. These findings highlight a specific alteration in iFC patterns associated with SN in patients with OCD and provide new insights into the dysfunctional brain organization of the SN in patients with OCD.

【 授权许可】

Unknown