Neurodevelopment of the incentive network facilitates motivated behaviour from adolescence to adulthood

NeuroImage

Silvia Brem¹  Iliana I. Karipidis²  Susanne Walitza²  Plamina Dimanova³  David Willinger³ 

[1] Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, 401 Quarry Rd Stanford, CA 94304, USA;Neuroscience Center Zurich, University of Zurich and ETH Zurich, Winterthurer Strasse 190, Zurich 8057, Switzerland;Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Neumünsterallee 9, Zurich 8032, Switzerland;

关键词: Adolescence;    Cortico-striatal;    Connectivity;    Development;    fMRI;    Prefrontal cortex;   

DOI  :  

来源: DOAJ

【 摘 要 】

The ability to enhance motivated performance through incentives is crucial to guide and ultimately optimise the outcome of goal-directed behaviour. It remains largely unclear how motivated behaviour and performance develops particularly across adolescence. Here, we used computational fMRI to assess how response speed and its underlying neural circuitry are modulated by reward and loss in a monetary incentive delay paradigm. We demonstrate that maturational fine-tuning of functional coupling within the cortico-striatal incentive circuitry from adolescence to adulthood facilitates the ability to enhance performance selectively for higher subjective values. Additionally, during feedback, we found developmental sex differences of striatal representations of reward prediction errors in an exploratory analysis. Our findings suggest that a reduced capacity to utilise subjective value for motivated behaviour in adolescence is rooted in immature information processing in the incentive system. This indicates that the neurocircuitry for coordination of incentivised, motivated cognitive control acts as a bottleneck for behavioural adjustments in adolescence.

【 授权许可】

Unknown