A developmental neurobiological model of motivated behavior: Anatomy, connectivity and ontogeny of the triadic nodes

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:33

Review

Ernst, Monique¹  Fudge, Julie L.² 

[1] Natl Inst Mental Hlth, Mood & Anxiety Disorders Program, NIH, Bethesda, MD 20892 USA

[2] Univ Rochester, Dept Psychiat & Neurobiol & Anat, Med Ctr, Rochester, NY 14642 USA

关键词: Amygdala;    Striatum;    Medial prefrontal cortex;    Adolescence;    Development;    Connectivity;    Motivated behavior;    Functional anatomy;    Approach;    Avoidance;    Regulatory system;    Triadic Model;   

DOI  :  10.1016/j.neubiorev.2008.10.009

来源: Elsevier

【 摘 要 】

Adolescence is the transition period that prepares individuals for fulfilling their role as adults. Most conspicuous in this transition period is the peak level of risk-taking behaviors that characterize adolescent motivated behavior. Significant neural remodeling contributes to this change. This review focuses on the functional neuroanatomy underlying motivated behavior, and how ontogenic changes can explain the typical behavioral patterns in adolescence. To help model these changes and provide testable hypotheses, a neural systems-based theory is presented. In short, the Triadic Model proposes that motivated behavior is governed by a carefully orchestrated articulation among three systems, approach, avoidance and regulatory. These three systems map to distinct, but overlapping, neural circuits, whose representatives are the striatum, the amygdala and the medial prefrontal cortex. Each of these system-representatives will be described from a functional anatomy perspective that includes a review of their connectivity and what is known of their ontogenic changes. Published by Elsevier Ltd.

【 授权许可】

Free