Substance abuse, adherence with antiretroviral therapy, and clinical outcomes among HIV-infected individuals

LIFE SCIENCES

卷:88

Review

Lucas, Gregory M.

关键词: HIV infection;    Substance abuse;    Adherence;    Addiction;   

DOI  :  10.1016/j.lfs.2010.09.025

来源: Elsevier

【 摘 要 】

Substance abuse and addiction are highly prevalent in HIV-infected individuals. Substance abuse is an important comorbidity that affects the delivery and outcomes of HIV medical management In this paper I will review data examining the associations between substance abuse and HIV treatment and potential strategies to improve outcomes in this population that warrant further investigation. Current but not past substance abuse adversely affects engagement in care, acceptance of antiretroviral therapy, adherence with therapy, and long-term persistence in care. Substance abuse treatment appears to facilitate engagement in HIV care, and access to evidence-based treatment for substance abuse is central to addressing the HIV epidemic. Strategies that show promise for HIV-infected substance abusers include integrated treatment models, directly observed therapy, and incentive-based interventions. (C) 2010 Elsevier Inc. All rights reserved.

【 授权许可】

Free