Executive dysfunction and reward dysregulation: A high-density electrical mapping study in cocaine abusers

NEUROPHARMACOLOGY

卷:85

Article

Morie, Kristen P.^1,2,3,4  De Sanctis, Pierfilippo^1,2  Garavan, Hugh^1,2,5  Foxe, John J.^1,2,3,4,5 

[1] Albert Einstein Coll Med, Dept Pediat, Childrens Evaluat & Rehabil Ctr, Sheryl & Daniel R Tishman Cognit Neurophysiol Lab, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA

[3] CUNY City Coll, Dept Psychol, Program Cognit Neurosci, New York, NY 10031 USA

[4] CUNY City Coll, Dept Biol, New York, NY 10031 USA

[5] Univ Vermont, Dept Psychiat, Burlington, VT 05401 USA

关键词: Reward;    Inhibition;    Executive function;    EEG;    ERP;    Substance abuse;    Addiction;   

DOI  :  10.1016/j.neuropharm.2014.05.016

来源: Elsevier

【 摘 要 】

Executive function deficits and reward dysregulation, which mainly manifests as anhedonia, are well documented in drug abusers. We investigated specific aspects of executive function (inhibitory control and cognitive control), as well as anhedonia, in a cohort of current cocaine abusers in order to ascertain to what extent these factors are associated with more severe drug dependence. Participants filled out questionnaires relating to anhedonia and their addiction history. Participants also performed a response inhibition task while high-density event-related potentials (ERPs) were recorded. Electrophysiological responses to successful inhibitions (N2/P3 components) and to commission errors (ERN/Pe components) were compared between 23 current users of cocaine and 27 non(-)using controls. A regression model was performed to determine the association of our measures of reward dysregulation and executive function with addiction severity. As expected, cocaine users performed more poorly than controls on the inhibitory control task and showed significant electrophysiological differences. They were also generally more anhedonic than controls. Higher levels of anhedonia were associated with more severe substance use, whereas the level of executive dysfunction was not associated with more severe substance use. However, N2 amplitude was associated with duration of drug use. Further, inhibitory control and anhedonia were correlated, but only in controls. These data suggest that while executive dysfunction characterizes drug abuse, it is anhedonia, independent of executive dysfunction, that is most strongly associated with more severe use. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

Free