A new ethylene glycol-silane monolayer for highly-specific DNA detection on Silicon Chips

SURFACE SCIENCE

卷:604

Article

Carrara, Sandro¹  Cavallini, Andrea¹  Maruyama, Yuki²  Charbon, Edoardo^1,2  De Micheli, Giovanni¹ 

[1] Ecole Polytech Fed Lausanne, Swiss Fed Inst Technol Lausanne CH, Lausanne, Switzerland

[2] Tech Univ Delft NL, Delft, Netherlands

关键词: AFM;    Ethylene glycol materials;    Silanes;    Silicon chip;    Fluorescence;   

DOI  :  10.1016/j.susc.2010.08.025

来源: Elsevier

【 摘 要 】

Monolayer thin films with ethylene-glycol function onto gold surfaces by using thiols have been extensively investigated They have been proposed as precursors for applications to bio-detection where their hydrophilic character improves both specificity and sensitivity The aim of this letter is to characterize ethylene-glycol monolayer precursors formed onto silicon chips by using silanes The importance of the ethylene-glycol function is demonstrated by comparing with the well known 3-Aminopropyltriethoxysilane The different nano-scale structures of the two precursor monolayers are investigated by using atomic force microscopy (AFM) Longer wider and deeper grooves were measured in the images acquired on 3 Aminopropyltriethoxysilane Fluorescence investigation demonstrates that the presence of ethylene-glycol function improves target hybridization onto silicon chips assuring highly-specific detection of DNA (C) 2010 Elsevier B V All rights reserved

【 授权许可】

Free