The Columbia University proton-induced soft X-ray microbeam

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS

卷:269

Article

Harken, Andrew D.¹  Randers-Pehrson, Gerhard¹  Johnson, Gary W.¹  Brenner, David J.¹ 

[1] Columbia Univ, Ctr Radiol Res, New York, NY 10032 USA

关键词: Soft X-ray;    Microbeam;    PIXE;   

DOI  :  10.1016/j.nimb.2011.05.033

来源: Elsevier

【 摘 要 】

A soft X-ray microbeam using proton-induced X-ray emission (PIXE) of characteristic titanium (K(alpha) 4.5 key) as the X-ray source has been developed at the Radiological Research Accelerator Facility (RARAF) at Columbia University. The proton beam is focused to a 120 mu m x 50 mu m spot on the titanium target using an electrostatic quadrupole quadruplet previously used for the charged particle microbeam studies at RARAF. The proton induced X-rays from this spot project a 50 mu m round X-ray generation spot into the vertical direction. The X-rays are focused to a spot size of 5 mu m in diameter using a Fresnel zone plate. The X-rays have an attenuation length of (1/e length of similar to 145 mu m) allowing more consistent dose delivery across the depth of a single cell layer and penetration into tissue samples than previous ultrasoft X-ray systems. The irradiation end station is based on our previous design to allow quick comparison to charged particle experiments and for mixed irradiation experiments. (C) 2011 Elsevier B.V. All rights reserved.

【 授权许可】

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