Administration of eicosapentaenoic and docosahexaenoic acids may improve the remodeling and browning in subcutaneous white adipose tissue and thermogenic markers in brown adipose tissue in mice

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:482

Article

Lonzetti Bargut, Thereza Cristina²  Martins, Fabiane Ferreira¹  Santos, Larissa Pereira¹  Aguila, Marcia Barbosa¹  Mandarim-de-Lacerda, Carlos A.¹ 

[1] Univ Estado Rio De Janeiro, Inst Biol, Biomed Ctr, Lab Morphometry Metab & Cardiovasc Dis, Rio De Janeiro, Brazil

[2] Fluminense Fed Univ, Nova Friburgo Hlth Inst, Basic Sci Dept, Nova Friburgo, Brazil

关键词: Adipose tissue;    Fructose;    Browning;    Uncoupling protein-1;    Thermogenesis;   

DOI  :  10.1016/j.mce.2018.12.003

来源: Elsevier

【 摘 要 】

The role of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in browning and thermogenesis has not been fully elucidated. Thus, we meant to evaluate the effect of EPA and DHA, administered alone or combined, with the activation of browning markers in subcutaneous white adipose tissue (sWAT), and thermogenic markers in brown adipose tissue (BAT). C57BL/6 adult male mice received a control diet or a high-fructose diet (HFru) for eight weeks, but after the first three weeks, HFru was divided into new groups: HFru, HFru + EPA, HFru + DHA, and HFru-EPA + DHA. EPA and DHA diminished adipocyte hypertrophy, recovered markers of browning in sWAT and thermogenic factors in the BAT, and improved gene expressions linked with mitochondrial biogenesis and lipid metabolism. Importantly, EPA and DHA administrated alone showed stronger results than the combination of EPA + DHA. The results suggest that EPA and DHA might be useful as adjuvant strategies to treat metabolic-associated disorders.

【 授权许可】

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