Estradiol to testosterone ratio in metabolic syndrome men aged started 40 years above

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Kusuma, R.^1 ; Siregar, Y.^1,2 ; Mardianto^3,4

Post Graduate Program of Biomedical Science, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia^1

Department of Biochemistry, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia^2

Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia^3

Division of Endocrine and Metabolism, RSUP H.Adam Malik, Medan, Indonesia^4

关键词: Adipose tissue;    Aromatase;    Metabolic syndromes;    Student t tests;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012164/pdf
DOI  :  10.1088/1755-1315/125/1/012164

来源: IOP

【 摘 要 】

Disruption of adipose tissue, an endocrine organ, could turn out into the so-called metabolic syndrome. Aging men with lowering testosterone were related to metabolic syndrome and excessive aromatase activity in adipose tissue would increase estradiol level. This study hypothesized that estradiol to testosterone ratio is increasedin aging, metabolic syndrome men. A total of 52 men were randomly recruited for this study. A blood samplewas drawn before 11.00 AM after 10 hoursof overnight fasting, then aliquot serum kept in -20°C pending the research. Subjects were divided evenly into the metabolic syndrome and nonmetabolicsyndrome group. The hormonal assaywas measured on the day of research. Then examined with student t-test. Estradiol level in metabolic syndrome group was increased, but insignificant differ to the other group. Testosterone level decreased and significantly different between groups. In conclusion, estradiol to testosterone ratio was increased in themetabolic syndrome group but insignificant.