Calcium, Barium and Strontium apatites: A new generation of catalysts in the Biginelli reaction

TETRAHEDRON

卷:73

Article

Ben Moussa, Sana¹  Lachheb, Jalel¹  Gruselle, Michel^2,3  Maaten, Birgit⁴  Kriis, Kadri⁵  Kanger, Tonis⁵  Tonsuaadu, Kaia⁶  Badraoui, Bechir¹ 

[1] Univ Monastir, Inst Preparatoire Etud Ingenieurs Monastir, UR Mat & Synth Organ UR 17E531, Monastir 5019, Tunisia

[2] CNRS, UMR 8232, Inst Parisien Chim Mol, F-75005 Paris, France

[3] UPMC Univ Paris 06, Sorbonne Univ, Inst Parisien Chim Mol, UMR 8232, F-75005 Paris, France

[4] Tallinn Univ Technol, Dept Energy Technol, Ehitajate Tee 5, EE-19086 Tallinn, Estonia

[5] Tallinn Univ Technol, Dept Chem & Biotechnol, Akad Tee 15, EE-12618 Tallinn, Estonia

[6] Tallinn Univ Technol, Lab Inorgan Mat, Ehitajate Tee 5, EE-19086 Tallinn, Estonia

关键词: Biginelli reaction;    Hydroxyapatite;    Modified hydroxyapatite;    Catalysis;   

DOI  :  10.1016/j.tet.2017.09.051

来源: Elsevier

【 摘 要 】

We describe herein the use of Calcium, Barium and Strontium hydroxyapatites (CaHAp, BaHAp and SrHAp) as well as CaHAp containing Magnesium, Copper, Zinc and Palladium (MgHAp, CuHAp, ZnHAp and PdHAp) as catalysts in the Biginelli reaction. The efficiency of CaHAp and SrHAp is very low, leading to the expected 3,4-dihydropyrimidin-2(1H)-one in poor yields. Mixed Ba(5)Sr(5)HAp and BaioHAp show interesting catalytic properties, especially BaioHAp leading to pure isolated reaction products in good yields. The use of modified CaHAp seems to be of interest in regard to the yield obtained. Nevertheless the release of Mg, Cu, Zn and Pd ions in the solution during the catalytic process makes the use of such modified apatites less effective. (C) 2017 Elsevier Ltd. All rights reserved.

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