An Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones Catalyzed by a Novel Brønsted Acidic Ionic Liquid under Solvent-Free Conditions

Molecules

Yonghong Zhang²  Bin Wang³  Xiaomei Zhang¹  Jianbin Huang²  Chenjiang Liu² 

[1] Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China; E-Mail:;Key Laboratory of Petroleum and Gas Fine Chemicals of Ministry of Education, School of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046, China; E-Mails:;Physics and Chemistry Detecting Center, Xinjiang University, Urumqi 830046, China; E-Mail:

关键词: [Btto][p-TSA];    Biginelli reaction;    dihydropyrimidinones;    solvent-free;   

DOI  :  10.3390/molecules20033811

来源: mdpi

【 摘 要 】

We report here an efficient and green method for Biginelli condensation reaction of aldehydes, β-ketoesters and urea or thiourea catalyzed by Brønsted acidic ionic liquid [Btto][p-TSA] under solvent-free conditions. Compared to the classical Biginelli reaction conditions, the present method has the advantages of giving good yields, short reaction times, near room temperature conditions and the avoidance of the use of organic solvents and metal catalyst.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.