In vivo wireless ethanol vapor detection in the Wistar rat

SENSORS AND ACTUATORS B-CHEMICAL

卷:138

Article

Cheney, C. Parks¹  Srijanto, B.¹  Hedden, D. L.¹  Gehl, A.¹  Ferrell, T. L.¹  Schultz, J.²  Engleman, E. A.²  McBride, W. J.²  O'Connor, S.² 

[1] Univ Tennessee, Dept Phys & Astron, Knoxville, TN 37996 USA

[2] Indiana Univ, Sch Med, Dept Psychiat, Inst Psychiat Res, Indianapolis, IN 46202 USA

关键词: Microcantilevers;    Piezoresistive;    Ethanol;    Biosensor;   

DOI  :  10.1016/j.snb.2009.01.052

来源: Elsevier

【 摘 要 】

Traditional alcohol studies measure blood alcohol concentration to elucidate the biomedical factors that contribute to alcohol abuse and alcoholism. These measurements require large and expensive equipment, are labor intensive, and are disruptive to the subject. To alleviate these problems, we have developed an implantable, wireless biosensor that is capable of measuring alcohol levels for up to 6weeks. Ethanol levels were measured in vivo in the interstitial fluid of a Wistar rat after administering 1 and 2 g/kg ethanol by intraperitoneal (IP) injection. The data were transmitted wirelessly using a biosensor selective for alcohol detection. A low-power piezoresistive microcantilever sensor array was used with a polymer coating suitable for measuring ethanol concentrations at 100% humidity over several hours. A hydrophobic, vapor permeable nanopore membrane was used to screen liquid and ions while allowing vapor to pass to the sensor from the subcutaneous interstitial fluid. (C) 2009 Elsevier B.V. All rights reserved.

【 授权许可】

Free