Modular micropumps fabricated by 3D printed technologies for polymeric microfluidic device applications

SENSORS AND ACTUATORS B-CHEMICAL

卷:342

Article

Alvarez-Brana, Y.^1,2  Etxebarria-Elezgarai, J.^1,6  de Larrinaga-Vicente, L. Ruiz^1,2  Benito-Lopez, F.^2,3,4  Basabe-Desmonts, L.^1,3,4,5 

[1] Univ Basque Country UPV EHU, BIOMICs Microfluid Grp, Lascaray Res Ctr, Microfluid Cluster UPV EHU, Vitoria, Spain

[2] Univ Basque Country UPV EHU, Dept Analyt Chem, Analyt Microsyst & Mat Lab, Microfluid Cluster UPV EHU,Chip AMMa LOAC Grp, Vitoria, Spain

[3] Microfluid Cluster UPV EHU, Bioaraba Hlth Res Inst, Vitoria, Spain

[4] Basque Ctr Mat Applicat & Nanostruct, BCMat, UPV EHU Sci Pk, Leioa, Spain

[5] Ikerbasque, Basque Fdn Sci, Maria Diaz Haroko Kalea 3, Bilbao 48013, Spain

[6] CIC NanoGUNE BRTA, Tolosa Hiribidea 76, Donostia San Sebastian 20018, Spain

关键词: Self-powered microfluidics;    Micropumps;    Degas driven flow;    3D printing;    Stereolithography;    Starch-lugol reaction;   

DOI  :  10.1016/j.snb.2021.129991

来源: Elsevier

【 摘 要 】

In order to facilitate the implementation of microfluidic technology for rapid point-of-care analysis, there is a demand for self-powered microfluidics. The modular architecture of degas driven plug-and-play polymeric micropumps and microfluidic cartridges arose during last decade as a powerful strategy for autonomous flow control. So far, reported polymeric micropumps were made of poly-dimethyl siloxane and were fabricated by casting. In this work, we showed that the advantages of three-dimensional printing can greatly benefit the development of modular micropumps. In addition, micropumps were created with a geometry that cannot be manufactured with conventional techniques, making it easily assemblable to microfluidic devices. Four types of polymeric resins and three printing methods were used to create a set of functional micropumps. It was shown that the material and the design of the printed micropumps were related to their power, making them tuneable and programmable. Finally, as proof of concept, a self-powered colorimetric test for the detection of starch was demonstrated. Three-dimensional printed micropumps emerge as an innovative element in the field of selfpowered microfluidics, which may be the key to develop integrated microsystems for several applications such as in rapid point-of-care analysis.

【 授权许可】

Free