Bioceramic scaffolds by additive manufacturing for controlled delivery of the antibiotic vancomycin

Estonian Academy of Sciences. Proceedings

Nikhil Kamboj¹ 

关键词: selective laser melting;    3D printing;    bioceramic scaffolds;    drug delivery.;   

DOI  :  10.3176/proc.2019.2.10

学科分类：化学（综合）

来源: Teaduste Akadeemia Kirjastus

【 摘 要 】

Silicon–calcium silicate scaffolds were fabricated by selective laser melting (SLM). Rectangular composite scaffoldswith a pore size of 400 μm were designed with dimensions of 10 × 20 × 5 mm3. For imparting controlled drug release capability,scaffolds were covered with polycaprolactone (PCL) coatings for the sustained delivery of vancomycin. The drug release profileof the coated scaffolds was studied by UV–visible spectroscopy. The encapsulated drug within the PCL coated scaffold exhibiteda controlled release of vancomycin. Nearly 50% of the vancomycin release from the scaffolds was observed during the first 40 hfollowed by the sustained release of vancomycin of nearly 20% of the actual loaded drug for the next six days. These findingssuggest that SLM synthesized scaffolds with PCL coating can expand their applicability to be used as a target for Staphylococciaureus bacteria, which often cause chronic infections such as chronic osteomyelitis in bone.

【 授权许可】

CC BY-NC