Bone Conduction Capacity of Highly Porous 3D-Printed Titanium Scaffolds Based on Different Pore Designs

Materials

Miyoung Ryu¹  Ui-Lyong Lee²  Young-Jun Choi²  In-Seok Song³  Ho-Kyung Lim⁴  Su-Heon Woo⁵ 

[1] CUSMEDI Inc., Sungnam 13217, Korea;Department of Oral & Maxillofacial Surgery, Chungang University Hospital, Seoul 03080, Korea;Department of Oral and Maxillofacial Surgery, Korea University Anam Hospital, Seoul 02841, Korea;Department of Oral and Maxillofacial Surgery, Korea University Guro Hospital, Seoul 08308, Korea;R&D Center, Medyssey Co., Ltd., Jechon 27159, Korea;

关键词: titanium scaffolds;    3D printing;    pore design;    selective laser melting;   

DOI  :  10.3390/ma14143892

来源: DOAJ

【 摘 要 】

In porous titanium scaffolds manufactured via 3D printing, the differences in bone formation according to pore design and implantation period were studied. Titanium scaffolds with three types of different pore structures (Octadense, Gyroid, and Dode) were fabricated via 3D printing using the selective laser melting method. Mechanical properties of scaffolds were investigated. Prepared specimens were inserted into both femurs of nine rabbits and their clinical characteristics were observed. Three animals were sacrificed at the 2nd, 4th, and 6th weeks, and the differences in bone formation were radiologically and histologically analyzed. The percentage of new bone and surface density in the pore structure were observed to be approximately 25% and 8 mm²/mm³, respectively. There was no difference in the amount of newly formed bone according to the pore design at 2, 4, and 6 weeks. In addition, no differences in the amount of newly formed bone were observed with increasing time within the same pore design for all three designs. During the 6-week observation period, the proportion of new bones in the 3D-printed titanium scaffold was approximately 25%. Differences in bone formation according to the pore design or implantation period were not observed.

【 授权许可】

Unknown