Reduced sulfate plasma concentrations in the BTBR T plus tf/J mouse model of autism

PHYSIOLOGY & BEHAVIOR

卷:107

Article

Corley, Michael J.^1,2  Meyza, Ksenia Z.²  Blanchard, D. Caroline²  Blanchard, Robert J.^1,2 

[1] Univ Hawaii, Dept Psychol, Honolulu, HI 96822 USA

[2] Univ Hawaii, Pacific Biosci Res Ctr, Honolulu, HI 96822 USA

关键词: Autism spectrum disorders;    Animal model;    BTBR;    Sulfate;   

DOI  :  10.1016/j.physbeh.2012.04.010

来源: Elsevier

【 摘 要 】

Clinical studies have shown that children diagnosed with autism show abnormal sulfate chemistry, which is critical for cellular and metabolic processes. To determine if the inbred BTBR T+tf/J mouse shows autism-relevant aberrations in sulfate chemistry, the present study examined plasma sulfate concentrations in BTBR T+tf/J, inbred C57BL/6J, and outbred CD-1 mice. Results showed that the BTBR T+tf/J mouse exhibits significantly lower plasma sulfate concentrations in comparison to both C57BL/6J and CD-1 mice. These results suggest that the BTBR mouse shows autism-relevant abnormalities in sulfate chemistry and may serve additional utility in examining the role of sulfate and sulfate-dependent systems in relation to autism-relevant behavioral aberrations. (C) 2012 Elsevier Inc. All rights reserved.

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