High-resolution MRI data of the brain of C57BL/6J and BTBR mice in three anatomical views

Data in Brief

Nikita G. Sozonov¹  Natalya P. Bondar¹  Yulia A. Ryabushkina²  Polina E. Kisaretova²  Vasiliy V. Reshetnikov²  Oleg B. Shevelev²  Kseniya A. Ayriyants² 

[1] Novosibirsk State University, Pirogova Street 2, Novosibirsk 630090, Russia;Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), Prospekt Lavrentyeva 10, Novosibirsk 630090, Russia;

关键词: BTBR;    C57BL/6J;    Early-life stress;    MRI;    Brain anatomy;    Strain-specific;   

DOI  :  

来源: DOAJ

【 摘 要 】

The research on strain-, sex-, and stress-specific differences in structural and functional connectivity of the brain is important for elucidating various behavioral features and etiologies of psychiatric disorders. Socially impaired BTBR mice are considered a model of autism spectrum disorders. Here we present high-resolution magnetic resonance imaging data from the brain of 89 adolescent mice (C57BL/6J and BTBR) in axial, sagittal, and coronal views. The study [1] includes both females and males differed in early-life experience (normally reared or subjected to prolonged maternal separation: 3 h daily from postnatal day 2 to 15). The MRI data were obtained on a horizontal tomograph Biospec 117/16 instrument with a magnetic field strength of 11.7 T. Thus, multislice Turbo RARE T2-weighted images of the brain were captured in eight groups of mice. Altogether, these data allow to evaluate strain-, sex-, and stress-specific alterations in the volumes of various brain structures and to better understand the relation between brain structural differences and behavioral abnormalities.

【 授权许可】

Unknown