Deficits in GABAB receptor system in schizophrenia and mood disorders: A postmortem study

SCHIZOPHRENIA RESEARCH

卷:128

Article

Fatemi, S. Hossein^1,2,3  Folsom, Timothy D.¹  Thuras, Paul D.⁴ 

[1] Univ Minnesota, Dept Psychiat, Sch Med, Div Neurosci Res, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Sch Med, Dept Pharmacol, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Sch Med, Dept Neurosci, Minneapolis, MN 55455 USA

[4] VA Med Ctr, Dept Psychiat, Minneapolis, MN 55417 USA

关键词: GABA(B) receptor;    Schizophrenia;    Bipolar disorder;    Major depression;    Lateral cerebellum;   

DOI  :  10.1016/j.schres.2010.12.025

来源: Elsevier

【 摘 要 】

Postmortem and genetic studies have clearly demonstrated changes in GABA(B) receptors in neuropsychiatric disorders such as autism, bipolar disorder, major depression, and schizophrenia. Moreover, a number of recent studies have stressed the importance of cerebellar dysfunction in these same disorders. In the current study, we examined protein levels of the two GABA(B) receptor subunits GABBR1 and GABBR2 in lateral cerebella from a well-characterized cohort of subjects with schizophrenia (n = 15), bipolar disorder (n = 14), major depression (n = 13) and healthy controls (n = 12). We found significant reductions in protein for both GABBR1 and GABBR2 in lateral cerebella from subjects with schizophrenia, bipolar disorder and major depression when compared with controls. These results provide further evidence of GABAergic dysfunction in these three disorders as well as identify potential targets for therapeutic intervention. (C) 2011 Elsevier B.V. All rights reserved.

【 授权许可】

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