The German research consortium for the study of bipolar disorder (BipoLife): a magnetic resonance imaging study protocol

International Journal of Bipolar Disorders

Christoph Mulert¹  Jens Sommer²  Catherine Hindi Attar³  Felix Bermpohl³  Michael Bauer⁴  Andrea Pfennig⁴  Philipp S. Ritter⁴  Verena Schuster⁵  Irina Falkenberg⁵  Tilo Kircher⁵  Christoph Vogelbacher⁵  Andreas Jansen⁶  Miriam H. A. Bopp⁷  Silke Matura⁸  Andreas Reif⁸  Georg Juckel⁹  Vera Flasbeck⁹  Udo Dannlowski^1,10  Dominik Grotegerd^1,10  Martin Hautzinger^1,11  Jens Treutlein^1,12  Lisa Rauer^1,12  Karolin E. Einenkel^1,12  Oliver Gruber^1,12 

[1] Center for Mind, Brain, and Behavior (CMBB), Universities of Marburg and Gießen, Marburg, Germany;Center of Psychiatry, Justus-Liebig University, Giessen, Germany;Giessen Graduate School for Life Sciences, Justus-Liebig University, Giessen, Germany;Center for Mind, Brain, and Behavior (CMBB), Universities of Marburg and Gießen, Marburg, Germany;Core-Facility Brainimaging, Faculty of Medicine, University Marburg, Marburg, Germany;Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy, Charité at St. Hedwig-Krankenhaus, Berlin, Germany;Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany;Department of Psychiatry and Psychotherapy, University of Marburg, Rudolf-Bultmann-Straße 8, 35039, Marburg, Germany;Center for Mind, Brain, and Behavior (CMBB), Universities of Marburg and Gießen, Marburg, Germany;Department of Psychiatry and Psychotherapy, University of Marburg, Rudolf-Bultmann-Straße 8, 35039, Marburg, Germany;Center for Mind, Brain, and Behavior (CMBB), Universities of Marburg and Gießen, Marburg, Germany;Core-Facility Brainimaging, Faculty of Medicine, University Marburg, Marburg, Germany;Department of Psychiatry and Psychotherapy, University of Marburg, Rudolf-Bultmann-Straße 8, 35039, Marburg, Germany;Center for Mind, Brain, and Behavior (CMBB), Universities of Marburg and Gießen, Marburg, Germany;Department of Neurosurgery, University Marburg, Marburg, Germany;Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany;Department of Psychiatry, Psychotherapy and Preventive Medicine, LWL University Hospital, Ruhr University Bochum, Bochum, Germany;Department of Psychiatry, University of Münster, Münster, Germany;Department of Psychology Clinical Psychology and Psychotherapy, Eberhard Karls University, Tübingen, Germany;Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany;

关键词: BipoLife;    Bipolar disorder;    Major depression;    fMRI;    MRI quality assurance;    Multicenter study;    Early recognition;    Early intervention;   

DOI  :  10.1186/s40345-021-00240-6

来源: Springer

【 摘 要 】

BackgroundBipolar disorder is one of the most severe mental disorders. Its chronic course is associated with high rates of morbidity and mortality, a high risk of suicide and poor social and occupational outcomes. Despite the great advances over the last decades in understanding mental disorders, the mechanisms underlying bipolar disorder at the neural network level still remain elusive. This has severe consequences for clinical practice, for instance by inadequate diagnoses or delayed treatments. The German research consortium BipoLife aims to shed light on the mechanisms underlying bipolar disorders. It was established in 2015 and incorporates ten university hospitals across Germany. Its research projects focus in particular on individuals at high risk of bipolar disorder, young patients in the early stages of the disease and patients with an unstable highly relapsing course and/or with acute suicidal ideation.MethodsFunctional and structural magnetic resonance imaging (MRI) data was acquired across nine sites within three different studies. Obtaining neuroimaging data in a multicenter setting requires among others the harmonization of the acquisition protocol, the standardization of paradigms and the implementation of regular quality control procedures. The present article outlines the MRI imaging protocols, the acquisition parameters, the imaging paradigms, the neuroimaging quality assessment procedures and the number of recruited subjects.DiscussionThe careful implementation of a MRI study protocol as well as the adherence to well-defined quality assessment procedures is one key benchmark in the evaluation of the overall quality of large-scale multicenter imaging studies. This article contributes to the BipoLife project by outlining the rationale and the design of the MRI study protocol. It helps to set the necessary standards for follow-up analyses and provides the technical details for an in-depth understanding of follow-up publications.

【 授权许可】

CC BY