A longitudinal magnetic resonance spectroscopy study investigating effects of risperidone in the anterior cingulate cortex and hippocampus in schizophrenia

SCHIZOPHRENIA RESEARCH

卷:210

Article

Kraguljac, Nina, V¹  Morgan, Charity J.²  Reid, Meredith A.³  White, David M.¹  Jindal, Ripu D.^1,4  Sivaraman, Soumya¹  Martinak, Bridgette K.¹  Lahti, Adrienne C.¹ 

[1] Univ Alabama Birmingham, Dept Psychiat & Behav Neurobiol, SC 501,1720 7th Ave S, Birmingham, AL 35294 USA

[2] Univ Alabama Birmingham, Dept Biostat, Birmingham, AL 35294 USA

[3] Auburn Univ, Dept Elect & Comp Engn, MRI Res Ctr, Auburn, AL 36849 USA

[4] Birmingham VA Med Ctr, Dept Neurol, Birmingham, AL USA

关键词: Magnetic resonance spectroscopy (MRS);    Glutamate;    Hippocampus;    Anterior cingulate cortex;    Treatment response;    Schizophrenia;   

DOI  :  10.1016/j.schres.2018.12.028

来源: Elsevier

【 摘 要 】

Magnetic Resonance Spectroscopy is a popular approach to probe brain chemistry in schizophrenia (SZ), but no consensus exists as to the extent of alterations. Thismay be attributable to differential effects of populations studied, brain regions examined, or antipsychotic medication effects. Here, wemeasured neurometabolites in the anterior cingulate cortex (ACC) and hippocampus, two structurally dissimilar brain regions implicated in the SZ pathophysiology. We enrolled 61 SZwith the goal to scan thembefore and after sixweeks of treatment with risperidone. We also scanned 31matched healthy controls twice, sixweeks apart. Using mixed effect repeatedmeasures linear models to examine the effect of group and time on metabolite levels in each voxel, we report an increase in hippocampal glutamate + glutamine (Glx) in SZ compared to controls (p=0.043), but no effect of antipsychotic medication (p=0.330). In the ACC, we did not find metabolite alterations or antipsychotic medication related changes after six weeks of treatment with risperidone. The coefficients for the discriminant function (differentiating SZ from HC) in the ACC were greatest for NAA (-0.83), and in the hippocampus for Glx (0.76), the same metabolites were associated with greater treatment response in patients at trend level. Taken together, our data extends the existing literature by demonstrating regionally distinct metabolite alterations in the same patient group and suggests that antipsychotic medications may have limited effects on metabolite levels in these regions. (C) 2019 Elsevier B.V. All rights reserved.

【 授权许可】

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