Age-related changes in anterior cingulate cortex glutamate in schizophrenia: A 1H MRS Study at 7 Tesla

SCHIZOPHRENIA RESEARCH

卷:172

Article

Brandt, Allison S.¹  Unschuld, Paul G.²  Pradhan, Subechhya^3,4  Lim, Issel Anne L.^3,4  Churchill, Gregory¹  Harris, Ashley D.^3,4  Hua, Jun^3,4  Barker, Peter B.^3,4  Ross, Christopher A.^1,5,6,7,8  van Zijl, Peter C. M.^3,4  Edden, Richard A. E.^3,4  Margolis, Russell L.^1,5,6 

[1] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21287 USA

[2] Univ Zurich, Div Psychiat Res & Psychogeriatr Med, Lab Aging Neurosci & Neuroimaging, Zurich, Switzerland

[3] Johns Hopkins Univ, Sch Med, Div MR Res, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD 21287 USA

[4] Kennedy Krieger Inst, FM Kirby Res Ctr Funct Brain Imaging, Baltimore, MD USA

[5] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21287 USA

[6] Johns Hopkins Univ, Sch Med, Program Cellular & Mol Med, Baltimore, MD 21287 USA

[7] Johns Hopkins Univ, Sch Med, Dept Pharmacol, Baltimore, MD 21287 USA

[8] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21287 USA

关键词: Schizophrenia;    Glutamate;    Anterior cingulate cortex;    Magnetic resonance spectroscopy;    7 T;   

DOI  :  10.1016/j.schres.2016.02.017

来源: Elsevier

【 摘 要 】

The extent of age-related changes in glutamate and other neurometabolites in the anterior cingulate cortex (ACC) in individuals with schizophrenia remain unclear. Magnetic resonance spectroscopy (MRS) at 7 T, which yields precise measurements of various metabolites and can distinguish glutamate from glutamine, was used to determine levels of ACC glutamate and other metabolites in 24 individuals with schizophrenia and 24 matched controls. Multiple regression analysis revealed that ACC glutamate decreased with age in patients but not controls. No changes were detected in levels of glutamine, N-acetylaspartate, N-acetylaspartylglutamic acid, myo-inositol, GABA, glutathione, total creatine, and total choline. These results suggest that age may be an important modifier of ACC glutamate in schizophrenia. (C) 2016 Elsevier B.V. All rights reserved.

【 授权许可】

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