Regional differences in expression of β-tubulin isoforms in schizophrenia

SCHIZOPHRENIA RESEARCH

卷:135

Article

Moehle, Mark S.²  Luduena, Richard F.³  Haroutunian, Vahram⁴  McCullumsmith, Robert E.¹ 

[1] Univ Alabama Birmingham, Sch Med, Civitan Int Res Ctr, Dept Psychiat & Behav Neurobiol, Birmingham, AL 35294 USA

[2] Univ Alabama Birmingham, Grad Program Neurosci, Birmingham, AL 35294 USA

[3] Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem, San Antonio, TX 78229 USA

[4] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA

关键词: Postmortem;    Western blot;    Anterior cingulate cortex;    Dorsal lateral prefrontal cortex;   

DOI  :  10.1016/j.schres.2011.12.010

来源: Elsevier

【 摘 要 】

A growing body of evidence suggests that abnormal elements of the cytoskeleton may be associated with the pathophysiology of schizophrenia. Isoforms of a major cytoskeleton protein, beta-tubulin, were recently demonstrated to have distinct roles in neuronal differentiation and cell viability. For these reasons, we tested the hypothesis that there are differences in the expression of beta-tubulin isoforms (beta I-beta IV) in the brain in schizophrenia, using western blot analysis in an elderly group of subjects with this illness and a control group. We found that beta I-tubulin protein expression was decreased in the anterior cingulate cortex and increased in the dorsolateral prefrontal cortex, but not changed in superior temporal gyrus or hippocampus in schizophrenia. Our data supports the growing body of evidence suggesting abnormalities of the cytoskeleton in schizophrenia. (C) 2012 Elsevier B.V. All rights reserved.

【 授权许可】

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