Laminar and cellular analyses of reduced somatostatin gene expression in the subgenual anterior cingulate cortex in major depression

NEUROBIOLOGY OF DISEASE

卷:73

Article

Seney, Marianne L.^1,2  Tripp, Adam¹  McCune, Samuel¹  Lewis, David A.^1,2  Sibille, Etienne^1,3,4 

[1] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA

[2] Univ Pittsburgh, Ctr Neurosci, Pittsburgh, PA 15260 USA

[3] Univ Toronto, Dept Psychiat, Campbell Family Res Inst, Ctr Addict & Mental Hlth, Toronto, ON, Canada

[4] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada

关键词: Somatostatin;    Depression;    Postmortem;    Anterior cingulate cortex;   

DOI  :  10.1016/j.nbd.2014.10.005

来源: Elsevier

【 摘 要 】

Somatostatin (SST), a neuropeptide expressed in dendritic-targeting gamma-aminobutyric acid (GABA) neurons, is decreased across corticolimbic areas in major depressive disorder (MDD). SST-positive GABA neurons form heterogeneous subgroups with different laminar distributions and electrophysiological properties, so knowing the anatomical and cellular localization of reduced SST may provide insight into the nature of the pathology in MDD. In cohorts of MDD subjects with known reduction of SST in postmortem sgACC gray matter, we used in situ hybridization to quantify the laminar and cellular patterns of altered SST mRNA expression. SST mRNA levels were lower across all cortical layers in the MDD subjects. Expression levels per cell were also lower, but the density of labeled neurons did not differ between subject groups. Consistent with the previous tissue level analysis, differences were more robust in females. In summary, we report MDD-related reduction in SST expression per cell across cortical layers in sgACC, suggesting a general vulnerability of SST neurons independent of specific cell type. (C) 2015 Elsevier Inc. All rights reserved.

【 授权许可】

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