Gray matter volume reduction in rostral middle frontal gyrus in patients with chronic schizophrenia

SCHIZOPHRENIA RESEARCH

卷:123

Article

Kikinis, Z.¹  Fallon, J. H.²  Niznikiewicz, M.³  Nestor, P.^3,4  Davidson, C.¹  Bobrow, L.¹  Pelavin, P. E.¹  Fischl, B.^5,7  Yendiki, A.⁵  McCarley, R. W.³  Kikinis, R.⁶  Kubicki, M.^1,3  Shenton, M. E.^1,3,6 

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Psychiat Neuroimaging Lab,Dept Psychiat, Boston, MA 02215 USA

[2] Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA 92717 USA

[3] Harvard Univ, Med Sch Brockton, Clin Neurosci Div, Neurosci Lab,Dept Psychiat,VA Boston Healthcare S, Boston, MA USA

[4] Univ Massachusetts, Dept Psychol, Boston, MA 02125 USA

[5] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Charlestown, MA USA

[6] Harvard Univ, Sch Med, Brigham & Womens Hosp, Surg Planning Lab,Dept Radiol, Boston, MA 02215 USA

[7] MIT, CSAIL HST, Cambridge, MA 02139 USA

关键词: Schizophrenia;    Magnetic resonance imaging;    Middle frontal gyrus;    Dorsal lateral prefrontal cortex;    Working memory;   

DOI  :  10.1016/j.schres.2010.07.027

来源: Elsevier

【 摘 要 】

The dorsolateral prefrontal cortex (DLPFC) is a brain region that has figured prominently in studies of schizophrenia and working memory, yet the exact neuroanatomical localization of this brain region remains to be defined. DLPFC primarily involves the superior frontal gyrus and middle frontal gyrus (MFG). The latter, however is not a single neuroanatomical entity but instead is comprised of rostral (anterior, middle, and posterior) and caudal regions. In this study we used structural MRI to develop a method for parcellating MFG into its component parts. We focused on this region of DLPFC because it includes BA46, a region involved in working memory. We evaluated volume differences in MFG in 20 patients with chronic schizophrenia and 20 healthy controls. Mid-rostral MFG (MR-MFG) was delineated within the rostra! MFG using anterior and posterior neuroanatomical landmarks derived from cytoarchitectonic definitions of BA46. Gray matter volumes of MR-MFG were then compared between groups, and a significant reduction in gray matter volume was observed (p < 0.008), but not in other areas of MFG (i.e., anterior or posterior rostra! MFG, or caudal regions of MFG). Our results demonstrate that volumetric alterations in MFG gray matter are localized exclusively to MR-MFG. 3D reconstructions of the cortical surface made it possible to follow MFG into its anterior part, where other approaches have failed. This method of parcellation offers a more precise way of measuring MR-MFG that will likely be important in further documentation of DLPFC anomalies in schizophrenia. (C) 2010 Elsevier B.V. All rights reserved.

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