Reduced cortical thickness in right Heschl’s gyrus associated with auditory verbal hallucinations severity in first-episode schizophrenia

BMC Psychiatry

Zhimin Xue³  Baoci Shan⁶  Zhening Liu³  Haihong Liu⁴  Qing Yang²  Tumbwene E. Mwansisya⁵  Yinnan Song⁶  Weidan Pu¹  Shengxiang Liang⁶  Xudong Chen³ 

[1] Medical Psychological Institute of the Second Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China;Department of Medicine, Yale-New Haven Hospital, Yale School of Medicine, New Haven, CT, USA;Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha 410011, Hunan, People’s Republic of China;Mental Health Center of Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China;Department of Clinical Nursing and Community Health, the University of Dodoma, Dodoma, Tanzania;Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, People’s Republic of China

关键词: Heschl’s gyrus;    Magnetic resonance imaging;    Cortical thickness;    Auditory hallucination;    Schizophrenia;   

Others  :  1217891
DOI  :  10.1186/s12888-015-0546-2

 received in 2015-03-17, accepted in 2015-06-30,  发布年份 2015

【 摘 要 】

Background

Auditory verbal hallucinations (AVHs) represent one of the most intriguing phenomena in schizophrenia, however, brain abnormalities underlying AVHs remain unclear. The present study examined the association between cortical thickness and AVHs in first-episode schizophrenia.

Method

High-resolution MR images were obtained in 49 first-episode schizophrenia (FES) patients and 50 well-matched healthy controls (HCs). Among the FES patients, 18 suffered persistent AVHs (“auditory hallucination” AH group), and 31 never experienced AVHs (“no hallucination” NH group). The severity of AVHs was rated by the Auditory Hallucinations Rating Scale (AHRS). Cortical thickness differences among the three groups and their association with AVHs severity were examined.

Results

Compared to both HCs and NH patients, AH patients showed lower cortical thickness in the right Heschl’s gyrus. The degree of reduction in the cortical thickness was correlated with AVH severity in the AH patients.

Conclusions

Abnormalities of cortical thickness in the Heschl’s gyrus may be a physiological factor underlying auditory verbal hallucinations in schizophrenia.

【 授权许可】

   
2015 Chen et al.

【 图 表 】

Fig. 1.

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