In search of antiepileptogenic treatments for post-traumatic epilepsy

NEUROBIOLOGY OF DISEASE

卷:123

Review

Saletti, Patricia G.¹  Ali, Idrish^2,3  Casillas-Espinosa, Pablo M.^2,3  Semple, Bridgette D.^2,3  Lisgaras, Christos Panagiotis¹  Moshe, Solomon L.^1,4,5  Galanopoulou, Aristea S.^1,4 

[1] Albert Einstein Coll Med, Saul R Korey Dept Neurol, Lab Dev Epilepsy, Bronx, NY 10467 USA

[2] Monash Univ, Alfred Hosp, Cent Clin Sch, Dept Neurosci, Melbourne, Vic, Australia

[3] Univ Melbourne, Royal Melbourne Hosp, Dept Med, Melbourne, Vic, Australia

[4] Montefiore Med Ctr, Albert Einstein Coll Med, Einstein Montefiore Epilepsy Ctr, Dominick P Purpura Dept Neurosci,Lab Dev Epilepsy, Bronx, NY 10467 USA

[5] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Pediat, Einstein Montefiore Epilepsy Ctr, Bronx, NY 10467 USA

关键词: Inflammation;    Tau;    Neurodegeneration;    Iron;    Traumatic brain injury;    Outcomes;    Antiepileptogenesis;    Disease modification;    Preclinical trial;   

DOI  :  10.1016/j.nbd.2018.06.017

来源: Elsevier

【 摘 要 】

Post-traumatic epilepsy (PTE) is diagnosed in 20% of individuals with acquired epilepsy, and can impact significantly the quality of life due to the seizures and other functional or cognitive and behavioral outcomes of the traumatic brain injury (TBI) and PTE. There is no available antiepileptogenic or disease modifying treatment for PTE. Animal models of TBI and PTE have been developed, offering useful insights on the value of inflammatory, neurodegenerative pathways, hemorrhages and iron accumulation, calcium channels and other target pathways that could be used for treatment development. Most of the existing preclinical studies test efficacy towards pathologies of functional recovery after TBI, while a few studies are emerging testing the effects towards induced or spontaneous seizures. Here we review the existing preclinical trials testing new candidate treatments for TBI sequelae and PTE, and discuss future directions for efforts aiming at developing antiepileptogenic and disease modifying treatments.

【 授权许可】

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