In search of antiepileptogenic treatments for post-traumatic epilepsy

Neurobiology of Disease

Pablo M. Casillas-Espinosa¹  Christos Panagiotis Lisgaras¹  Aristea S. Galanopoulou¹  Idrish Ali²  Bridgette D. Semple²  Solomon L. Moshé²  Patricia G. Saletti³ 

[1] Department of Medicine (Royal Melbourne Hospital), The University of Melbourne, Melbourne, Australia;Department of Neuroscience, Central Clinical School, Monash University, The Alfred Hospital, Melbourne, Australia;Saul R. Korey Department of Neurology, Laboratory of Developmental Epilepsy, Albert Einstein College of Medicine, Bronx, NY, USA;

关键词: Inflammation;    Tau;    Neurodegeneration;    Iron;    Traumatic brain injury;    Outcomes;   

DOI  :  

来源: DOAJ

【 摘 要 】

Post-traumatic epilepsy (PTE) is diagnosed in 20% of individuals with acquired epilepsy, and can impact significantly the quality of life due to the seizures and other functional or cognitive and behavioral outcomes of the traumatic brain injury (TBI) and PTE. There is no available antiepileptogenic or disease modifying treatment for PTE. Animal models of TBI and PTE have been developed, offering useful insights on the value of inflammatory, neurodegenerative pathways, hemorrhages and iron accumulation, calcium channels and other target pathways that could be used for treatment development. Most of the existing preclinical studies test efficacy towards pathologies of functional recovery after TBI, while a few studies are emerging testing the effects towards induced or spontaneous seizures. Here we review the existing preclinical trials testing new candidate treatments for TBI sequelae and PTE, and discuss future directions for efforts aiming at developing antiepileptogenic and disease-modifying treatments.

【 授权许可】

Unknown