Hypoxia in astrocytic tumors and implications for therapy

NEUROBIOLOGY OF DISEASE

卷:85

Review

Cavazos, David A.¹  Brenner, Andrew J.¹ 

[1] Univ Texas Hlth Sci Ctr San Antonio, Canc Therapy & Res Ctr, San Antonio, TX 78229 USA

关键词: Glioblastoma multiforme;    Astrocytic tumors;    Hypoxia;    Metabolic derangement;    Aerobic glycolysis;    TH-302;    CXCL12;    CXCR7;    Pseudopalisading necrosis;    Acetate;   

DOI  :  10.1016/j.nbd.2015.06.007

来源: Elsevier

【 摘 要 】

Glioblastoma (GBM, Grade IV astrocytoma) is the most common and most aggressive of the primary malignant brain tumors in adults. Hypoxia is a distinct feature in GBM and plays a significant role in tumor progression, resistance to treatment and poor outcomes. This review considers the effects of hypoxia on astrocytic tumors and the mechanisms that contribute to tumor progression and therapeutic resistance, with a focus on the vascular changes, chemotaxic signaling pathways and metabolic alterations involved. (C) 2015 Elsevier Inc. All rights reserved.

【 授权许可】

Free