Pediatric spinal glioblastoma of the conus medullaris: a case report of long survival

Cancer Communications

Andrea Carai¹  Francesca Diomedi-Camassei¹  Angela Mastronuzzi¹  Alessandro De Benedictis⁵  Giovanna Stefania Colafati⁵  Antonella Cacchione⁵  Maria Giuseppina Cefalo⁹  Michele Rizzi⁹ 

[1]Children’

[2], IRCCS, Milan, Italy

[3]Carlo Besta”

[4]Department of Neurosurgery, Fondazione Istituto Neurologico “

[5]Department of Pediatric Hematology-Oncology, Bambino Gesù

[6]Division of Pathology, Bambino Gesù

[7]Neuroradiology Unit, Bambino Gesù

[8]Neurosurgery Unit, Department of Neuroscience and Neurorehabilitation, Bambino Gesù

[9]s Hospital, IRCCS, Rome, Italy

[10]s Hospital, Rome, Italy

关键词: Spinal cord cancer;    Glioblastoma multiforme;    Children;    Multidisciplinary treatment;    Prognosis;   

DOI  :  10.1186/s40880-016-0107-1

学科分类：肿瘤学

来源: Springer

【 摘 要 】

High-grade gliomas of the spinal cord represent a rare entity in children. Their biology, behavior, and controversial treatment options have been discussed in a few pediatric cases. These tumors are associated with severe disability and poor prognosis. We report a case of a 4-year-old child diagnosed with an isolated glioblastoma multiforme of the conus medullaris. The patient underwent subtotal surgical excision, followed by adjuvant radiotherapy and oral chemotherapy. He is alive with mild neurologic deficits at 52 months after diagnosis. We describe the peculiar characteristics of this rare condition in pediatric oncology. We also provide an overview of current multidisciplinary therapeutic approaches and prognostic factors for this disease.

【 授权许可】

CC BY