Tetra-o-methyl nordihydroguaiaretic acid and Temozolomide work synergistically on Glioblastoma Multiforme tumors

Glioblastoma multiforme;tetra-O-methyl nordihydroguaiaretic acid;Biology

Baker, Nusaiba

Johns Hopkins University

关键词: Glioblastoma multiforme;    tetra-O-methyl nordihydroguaiaretic acid;    Biology;   

Others  :  https://jscholarship.library.jhu.edu/bitstream/handle/1774.2/37115/BAKER-THESIS-2014.pdf?sequence=1&isAllowed=y

瑞士|英语

来源: JOHNS HOPKINS DSpace Repository

【 摘 要 】

Glioblastoma multiforme (GBM) is a grade IV astrocytoma and one of the most malignant brain tumors. GBM responds poorly to the current treatment methods, temozolomide (TMZ) and radiation. Tetra-O-methyl-nordihydroguaiaretic acid (M4N), a global transcription repressor of genes, is potent when used on GBM cell lines. Here, we investigate the effects of M4N in combination with TMZ on GBM cell lines. Cell proliferation measurements and drug combination analyses using different schedules of administration were performed on GBM cell lines. We found that M4N worked synergistically with TMZ to decrease tumor cell proliferation. M4N also induced apoptotic cell death, and our results suggest future clinical applications of M4N in combination with TMZ for GBM treatment.