Oxidative stress and hippocampal synaptic protein levels in elderly cognitively intact individuals with Alzheimer's disease pathology

NEUROBIOLOGY OF AGING

卷:42

Article

Scheff, Stephen W.¹  Ansari, Mubeen A.¹  Mufson, Elliott J.² 

[1] Univ Kentucky, Dept Anat & Neurobiol, Sanders Brown Ctr Aging, Lexington, KY 40536 USA

[2] Barrow Neurol Inst, Dept Neurobiol, Phoenix, AZ 85013 USA

关键词: Synapses;    Neurodegeneration;    Dementia;    Aging;    Amyloid;    Hippocampus;    Temporal lobe;   

DOI  :  10.1016/j.neurobiolaging.2016.02.030

来源: Elsevier

【 摘 要 】

Neuritic amyloid plaques and neurofibrillary tangles are hallmarks of Alzheimer's disease (AD) and are major components used for the clinical diagnosis of this disorder. However, many individuals with no cognitive impairment (NCI) also present at autopsy with high levels of these AD pathologic hallmarks. In this study, we evaluated 15 autopsy cases from NCI individuals with high levels of AD-like pathology (high pathology no cognitive impairment) and compared them to age-and postmortem-matched cohorts of individuals with amnestic mild cognitive impairment and NCI cases with low AD-like pathology (low pathology no cognitive impairment [LPNCI]). Individuals classified as high pathology no cognitive impairment or amnestic mild cognitive impairment had a significant loss of both presynaptic and postsynaptic proteins in the hippocampus compared with those in the LPNCI cohort. In addition, these 2 groups had a significant increase in 3 different markers of oxidative stress compared with that in the LPNCI group. The changes in levels of synaptic proteins are strongly associated with levels of oxidative stress. These data suggest that cognitively older subjects without dementia but with increased levels of AD-like pathology may represent a very early preclinical stage of AD. (C) 2016 Elsevier Inc. All rights reserved.

【 授权许可】

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