Blood pressure is associated with higher brain amyloid burden and lower glucose metabolism in healthy late middle-age persons

NEUROBIOLOGY OF AGING

卷:33

Article

Langbaum, Jessica B. S.^1,2  Chen, Kewei^1,2,3  Launer, Lenore J.⁴  Fleisher, Adam S.^1,2,5  Lee, Wendy^1,2  Liu, Xiaofen^1,2  Protas, Hillary D.^1,2  Reeder, Stephanie A.^1,2  Bandy, Daniel^1,2  Yu, Meixiang¹  Caselli, Richard J.^2,6  Reiman, Eric M.^1,2,7,8 

[1] Banner Alzheimers Inst, Phoenix, AZ 85006 USA

[2] Arizona Alzheimers Consortium, Phoenix, AZ USA

[3] Arizona State Univ, Sch Math & Stat Sci, Tempe, AZ USA

[4] NIA, Lab Epidemiol, NIH, Bethesda, MD 20892 USA

[5] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA

[6] Mayo Clin Arizona, Dept Neurol, Scottsdale, AZ USA

[7] Univ Arizona, Dept Psychiat, Tucson, AZ USA

[8] Translat Genom Res Inst, Neurogen Div, Phoenix, AZ USA

关键词: APOE;    Blood pressure;    Arterial stiffness;    Brain imaging;    PET;    Alzheimer's disease;    Amyloid;    PiB;    Pittsburgh Compound-B;   

DOI  :  10.1016/j.neurobiolaging.2011.06.020

来源: Elsevier

【 摘 要 】

Epidemiological studies suggest that elevated blood pressure (BP) in midlife is associated with increased risk of Alzheimer's disease (AD) in late life. In this preliminary study, we investigated the extent to which BP measurements are related to positron emission tomography (PET) measurements of fibrillar amyloid-beta burden using Pittsburgh Compound-B (PiB) and fluorodeoxyglucose (FDG) PET measures of cerebral metabolic rate for glucose metabolism (CMRgl) in cognitively normal, late middle-aged to older adult apolipoprotein E (APOE) epsilon 4 homozygotes, heterozygotes and noncarriers. PiB PET results revealed that systolic BP (SBP) and pulse pressure (PP) were each positively correlated with cerebral-to-cerebellar PiB distribution volume ratio (DVR) in frontal, temporal, and posterior-cingulate/precuneus regions, whereas no significant positive correlations were found between PiB distribution volume ratios and diastolic BP (DBP). FDG PET results revealed significant inverse correlations between each of the BP measures and lower glucose metabolism in frontal and temporal brain regions. These preliminary findings provide additional evidence that higher BP, likely a reflection of arterial stiffness, during late midlife may be associated with increased risk of presymptomatic AD. (C) 2012 Elsevier Inc. All rights reserved.

【 授权许可】

Free