APOE and neuroenergetics: an emerging paradigm in Alzheimer's disease

NEUROBIOLOGY OF AGING

卷:34

Review

Wolf, Andrew B.^1,2  Caselli, Richard J.^2,3  Reiman, Eric M.^2,4,5,6,7  Valla, Jon^1,2 

[1] Midwestern Univ, Dept Biochem, Glendale, AZ 85308 USA

[2] Arizona Alzheimers Consortium, Phoenix, AZ USA

[3] Mayo Clin Arizona, Dept Neurol, Scottsdale, AZ USA

[4] Banner Alzheimers Inst, Phoenix, AZ USA

[5] Banner Good Samaritan PET Ctr, Phoenix, AZ USA

[6] Translat Genom Res Inst TGen, Neurogen Div, Phoenix, AZ USA

[7] Univ Arizona, Dept Psychiat, Phoenix, AZ USA

关键词: APOE;    Apolipoprotein E;    Mitochondria;    Neuroenergetics;    Brain imaging;    fMRI;    FDG PET;    Cytochrome oxidase;    Biomarkers;    Alzheimer's disease;    Energy metabolism;    Neurodegeneration;   

DOI  :  10.1016/j.neurobiolaging.2012.10.011

来源: Elsevier

【 摘 要 】

APOE is the major known genetic risk factor for late-onset Alzheimer's disease. Though relationships between APOE-encoded apolipoprotein E and beta-amyloid are increasingly well described, mounting evidence supports wide-ranging effects of APOE on the brain. Specifically, APOE appears to affect brain network activity and closely related neuroenergetic functions that might be involved in vulnerability to neurodegenerative pathophysiology. These effects highlight the salience of further investigation into the diverse influences of APOE. Therefore, this article reviews the interplay between APOE and neuroenergetics and proposes areas for further investigation. This research might lead to the identification of novel therapeutic targets for the treatment and/or prevention of Alzheimer's disease. (C) 2013 Elsevier Inc. All rights reserved.

【 授权许可】

Free