Arterial pulse pressure amplification described by means of a nonlinear wave model: characterization of human aging

20th Argentinean Bioengineering Society Congress

物理学;生物科学

Alfonso, M.^1 ; Cymberknop, L.^1 ; Armentano, R.^1,2 ; Pessana, F.^1,2 ; Wray, S.^1 ; Legnani, W.^1

Buenos Aires Regional Faculty, School of Advanced Studies in Engineering Sciences, National Technological University, Buenos Aires, Argentina^1

Faculty of Engineering Exact and Natural Sciences, Favaloro University, Buenos Aires, Argentina^2

关键词: Arterial stiffness;    Blood pressure waveform;    Compartmental model;    Morphological changes;    Nonlinear interactions;    Nonlinear mechanics;    Nonlinear waves;    Systemic circulation;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/705/1/012029/pdf
DOI  :  10.1088/1742-6596/705/1/012029

学科分类：生物科学（综合）

来源: IOP

【 摘 要 】

The representation of blood pressure pulse as a combination of solitons captures many of the phenomena observed during its propagation along the systemic circulation. The aim of this work is to analyze the applicability of a compartmental model for propagation regarding the pressure pulse amplification associated with arterial aging. The model was applied to blood pressure waveforms that were synthesized using solitons, and then validated by waveforms obtained from individuals from differentiated age groups. Morphological changes were verified in the blood pressure waveform as a consequence of the aging process (i.e. due to the increase in arterial stiffness). These changes are the result of both a nonlinear interaction and the phenomena present in the propagation of nonlinear mechanic waves.