A common genetic variant of the chromogranin A-derived peptide catestatin is associated with atherogenesis and hypertension in a Japanese population

Endocrine Journal

Yoshio Nakata²  Takeshi Otsuki⁷  Shinya Kuno⁴  Seiji Maeda⁴  Yasushi Kawakami⁹  Youngju Choi⁴  Yoshimi Iijima⁵  Kiyoji Tanaka⁴  Nitish R. Mahapatra³  Takehito Sugasawa⁴  Masahiro Miura⁹  Hitoshi Shimano⁸  Prasanna K. R. Allu³  Jun Sugawara¹  Kazuhiro Takekoshi²  Motoyuki Iemitsu⁶  Sumiko Nissato⁹ 

[1] Human Technology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba 305-8566, Japan;Faculty of Medicine, Division of Sports Medicine, University of Tsukuba, Tsukuba 305-8575, Japan;Department of Biotechnology, Indian Institute of Technology Madras, Chennai-600036, India;Division of Sports Medicine, Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba 305-8574, Japan;Department of Medical Genetics, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan;Faculty of Sport and Health Science, Ritsumeikan University, Kusatsu 525-8577, Japan;Faculty of Sport and Health Sciences, Ryutsu Keizai University, Ryugasaki 301-8555, Japan;Department of Endocrinology and Metabolism, University of Tsukuba, Tsukuba 305-8575, Japan;Department of Laboratory Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305-8575, Japan

关键词: Catestatin;    Pancreastatin;    Arterial stiffness;    Blood pressure;    Japanese;   

DOI  :  10.1507/endocrj.EJ14-0471

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(31)Chromogranin A (CHGA) is a major protein in the secretory granules of chromaffin cells.CHGA also gives rise to cardiovascular/metabolism regulatory peptides, such as catestatin (CST) and pancreastatin (PST).While CST is a potent inhibitor of catecholamine secretion, PST is a potent physiological inhibitor of glucose-induced insulin secretion.Recently, several SNPs were identified in the CST and PST domains of CHGA locus in different populations.Among the discovered SNPs, CST variant allele Ser-364 was associated with blood pressure alteration and PST variant allele Ser-297 was associated with significantly higher plasma glucose level.In this study, we examined whether these CST and PST variant alleles exist and influence cardiovascular and metabolic phenotypes in Japanese population. Our study comprised of 343 Japanese subjects aged 45-85 years (143 men and 200 women, mean age 66 ± 8 years).We determined the genotypes of CST and PST by PCR-direct sequencing method and carried out genotype-phenotype association analysis.In 343 participants, the minor allele frequency of CST variant Ser-364 was 6.10%.On the other hand, we did not detect the PST variant Ser-297 in this entire study population.The presence of Ser-364 allele was associated with increased in baPWV (an index of systemic arterial stiffness) that suggests an initiation and/or progression atherogenesis and hypertension.The Ser-364 allele was also associated with elevated systolic blood pressure and pulse pressure, consistent with increased baPWV.In conclusion, the CST Ser-364 allele may increase the risk for cardiovascular diseases in Japanese population.

【 授权许可】

Unknown