Reduced serotonin receptors and transporters in normal aging adults: a meta-analysis of PET and SPECT imaging studies

NEUROBIOLOGY OF AGING

卷:80

Article

Karrer, Teresa M.¹  McLaughlin, Casey L.²  Guaglianone, Carmela P.³  Samanez-Larkin, Gregory R.^3,4 

[1] Rhein Westfal TH Aachen, Fac Med, Dept Psychiat Psychotherapy & Psychosomat, Aachen, Germany

[2] Coll William & Mary, Dept Biol, Williamsburg, VA 23185 USA

[3] Duke Univ, Dept Psychol & Neurosci, Durham, NC USA

[4] Duke Univ, Ctr Cognit Neurosci, Durham, NC USA

关键词: Meta-analysis;    Serotonin;    Healthy aging;    Receptors;    Transporters;   

DOI  :  10.1016/j.neurobiolaging.2019.03.021

来源: Elsevier

【 摘 要 】

Alterations in serotonin (5-HT) function have been hypothesized to underlie a range of physiological, emotional, and cognitive changes in older age. Here, we conducted a quantitative synthesis and comparison of the effects of age on 5-HT receptors and transporters from cross-sectional positron emission tomography and single-photon emission computed tomography imaging studies. Random-effects meta-analyses of 31 studies including 1087 healthy adults yielded large negative effects of age in 5-HT-2A receptors (largest in global cortex), moderate negative effects of age in 5-HT transporters (largest in thalamus), and small negative effects of age in 5-HT-1A receptors (largest in parietal cortex). Presynaptic 5-HT-1A autoreceptors in raphe/midbrain, however, were preserved across adulthood. Adult age differences were significantly larger in 5-HT-2A receptors compared with 5-HT-1A receptors. A meta-regression showed that 5-HT target, radionuclide, and publication year significantly moderated the age effects. The findings overall identify reduced serotonergic signal transmission in healthy aging. The evidence for the relative preservation of 5-HT-1A compared with 5-HT-2A receptors may partially explain psychological age differences, such as why older adults use more emotion-focused rather than problem-focused coping strategies. (C) 2019 Elsevier Inc. All rights reserved.

【 授权许可】

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