Reduced dopamine receptors and transporters but not synthesis capacity in normal aging adults: a meta-analysis

NEUROBIOLOGY OF AGING

卷:57

Article

Karrer, Teresa M.^1,9  Josef, Anika K.^2,10  Mata, Rui³  Morris, Evan D.^4,5,6,7  Samanez-Larkin, Gregory R.^1,8,11 

[1] Yale Univ, Dept Psychol, New Haven, CT USA

[2] Max Planck Inst Human Dev, Ctr Adapt Rat, Berlin, Germany

[3] Univ Basel, Ctr Cognit & Decis Sci, Basel, Switzerland

[4] Yale Univ, Yale PET Ctr, New Haven, CT USA

[5] Yale Univ, Dept Biomed Engn, New Haven, CT USA

[6] Yale Univ, Dept Radiol & Biomed Imaging, New Haven, CT USA

[7] Yale Univ, Dept Psychiat, New Haven, CT 06520 USA

[8] Duke Univ, Ctr Cognit Neurosci, Box 90999, Durham, NC 27708 USA

[9] Rhein Westfal TH Aachen, Aachen, Germany

[10] VDI VDE Innovat Tech GmbH, Berlin, Germany

[11] Duke Univ, Durham, NC 27706 USA

关键词: Meta-analysis;    Healthy aging;    Dopamine;    Receptors;    Transporters;    Synthesis capacity;   

DOI  :  10.1016/j.neurobiolaging.2017.05.006

来源: Elsevier

【 摘 要 】

Many theories of cognitive aging are based on evidence that dopamine (DA) declines with age. Here, we performed a systematic meta-analysis of cross-sectional positron emission tomography and single-photon emission-computed tomography studies on the average effects of age on distinct DA targets (receptors, transporters, or relevant enzymes) in healthy adults (N = 95 studies including 2611 participants). Results revealed significant moderate to large, negative effects of age on DA transporters and receptors. Age had a significantly larger effect on D1- than D2-like receptors. In contrast, there was no significant effect of age on DA synthesis capacity. The average age reductions across the DA system were 3.7%-14.0% per decade. A meta-regression found only DA target as a significant moderator of the age effect. This study precisely quantifies prior claims of reduced DA functionality with age. It also identifies presynaptic mechanisms (spared synthesis capacity and reduced DA transporters) that may partially account for previously unexplained phenomena whereby older adults appear to use dopaminergic resources effectively. Recommendations for future studies including minimum required samples sizes are provided. (C) 2017 The Author(s). Published by Elsevier Inc.

【 授权许可】

Free