Aspectos neuroquímicos: o papel da serotonina no TOC

Revista Brasileira de Psiquiatria

Frederico G Graeff¹ 

[1] ,Universidade de São Paulo Faculdade de Medicina de Ribeirão Preto Departamento de Neurologia, Psiquiatria e Psicologia MédicaRibeirão Preto SP ,Brasil

关键词: Obsessive-compulsive disorder;    Receptors;    Serotonin;   

DOI  :  10.1590/S1516-44462001000600011

来源: SciELO

【 摘 要 】

The therapeutic action of selective serotonin (5-HT) reuptake inhibitors (SSRIs) in obsessive-compulsive disorder (OCD) points to the role of 5-HT in this condition. Functional neuroimaging studies showed hyperactivity of the nucleus caudatum in OCD patients, which disappears following treatment with either SSRIs or cognitive behavior therapy. Pharmacological results indicate hypersensitivity of the 5-HT1D receptor subtype in OCD, similarly reversed by chronic administration of SSRIs. Neurochemical data show that these receptors are selectively concentrated in the striatum, and are localized in 5-HT terminals, where they inhibit 5-HT release by the nerve impulse. Since 5-HT reduces the activity of post-synaptic neurons in the striatum, it has been suggested that the hypersensitivity of 5-HT1D receptors contribute to the genesis of OCD symptoms.

【 授权许可】

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