Ethanol Origin in Postmortem Urine: A LC/MS Determination of Serotonin Metabolites

Johnson RD, Lewis RL, Canfield DV, Blank CL

FAA Office of Aerospace Medicine - Civil Aerospace Medical Institute

关键词: Postmortem Ethanol;    LC/MS;    Serotonin;    5-hydroxytryptophol;    5-hydroxyindole-3-acetic Acid;    Aircraft Accident Investigation;   

RP-ID  :  DOT/FAA/AM-03/18

美国|英语

来源: Federal Aviation Administration

【 摘 要 】

Specimens from fatal aviation accident victims are submitted to the FAA Civil Aerospace Medical Institute for toxicological analysis. During toxicological evaluations, ethanol analysis is performed on all cases. Care must be taken when interpreting a positive ethanol result due to the potential for postmortem ethanol formation. Several indicators of postmortem ethanol formation exist; however, none are completely reliable. The consumption of ethanol has been shown to alter the concentration of two major serotonin metabolites, 5-hydroxytryptophol (5-HTOL) and 5 hydroxyindole-3-acetic acid (5-HIAA).