General Unknown Screening by Ion Trap LC/MS/MS

Johnson RD

FAA Office of Aerospace Medicine - Civil Aerospace Medical Institute

关键词: Forensic Toxicology;    General Unknown Screening;    LC/MS;   

RP-ID  :  DOT/FAA/AM-10/8

美国|英语

来源: Federal Aviation Administration

【 摘 要 】

During the investigation of aviation accidents, postmortem specimens from accident victims are submitted to the Federal Aviation Administration's Civil Aerospace Medical Institute (CAMI) for toxicological analysis. The first, and perhaps most important, step in the analysis process is the initial screening of biological specimens for illicit, medically prescribed, and over-the-counter compounds that may be present and could have been the cause of the accident. Currently, our General Unknown Screening (GUS) procedure involves both gas chromatography/mass spectrometry (GC/MS), liquid chromatography/diode array detection (LC/DAD) and fluorescence detection techniques.