Cognitive reserve and rate of change in Alzheimer's and cerebrovascular disease biomarkers among cognitively normal individuals

NEUROBIOLOGY OF AGING

卷:88

Article

Pettigrew, Corinne¹  Soldan, Anja¹  Zhu, Yuxin²  Cai, Qing³  Wang, Mei-Cheng²  Moghekar, Abhay¹  Miller, Michael, I⁴  Singh, Baljeet⁵  Martinez, Oliver⁵  Fletcher, Evan⁵  DeCarli, Charles⁵  Albert, Marilyn¹ 

[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biostat, Baltimore, MD USA

[3] Lyft Inc, San Francisco, CA USA

[4] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD USA

[5] Univ Calif Davis, Dept Neurol, Sch Med, Davis, CA 95616 USA

关键词: Cognitive reserve;    Alzheimer's disease;    Biomarkers;    Cerebrovascular disease;    Amyloid;    Tau;   

DOI  :  10.1016/j.neurobiolaging.2019.12.003

来源: Elsevier

【 摘 要 】

We examined whether cognitive reserve (CR) impacts level of, or rate of change in, biomarkers of Alzheimer's disease (AD) and small-vessel cerebrovascular disease in >250 individuals who were cognitively normal and middle-aged and older at the baseline. The four primary biomarker categories commonly examined in studies of AD were measured longitudinally: cerebrospinal fluid measures of amyloid (A) and tau (T); cerebrospinal fluid and neuroimaging measures of neuronal injury (N); and neuroimaging measures of white matter hyperintensities (WMHs) to assess cerebrovascular pathology (V). CR was indexed by a composite score including years of education, reading, and vocabulary test performance. Higher CR was associated with lower levels of WMHs, particularly among those who subsequently progressed from normal cognition to MCI. CR was not associated with WMH trajectories. In addition, CR was not associated with either levels of, or rate of change in, A/T/N biomarkers. This may suggest that higher CR is associated with lifestyle factors that reduce levels of cerebrovascular disease, allowing individuals with higher CR to better tolerate other types of pathology. (C) 2019 Elsevier Inc. All rights reserved.

【 授权许可】

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