The synthesis of clopidogrel

1st International Conference on Frontiers of Materials Synthesis and Processing

材料科学;化学

Huang, Yuanjun^1 ; Zhu, Qingxin^1

Yichun Vocational Technology College, Yichun

336000, China^1

关键词: Antiplatelet agent;    Cerebrovascular disease;    Industrial production;    Intermediate product;    Platelet aggregation;    Preparation method;    Pyridine derivatives;    Synthetic procedures;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/274/1/012077/pdf
DOI  :  10.1088/1757-899X/274/1/012077

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

Cardiac and cerebrovascular disease is a common disease. It is well recognized that antiplatelet agent is effective in the prevention and treatment of thrombosis. Clopidogrel is one of thieno pyridine derivatives, which can inhibit ADP-induced platelet aggregation. The preparation methods of Clopidogrel were reviewed and Clopidogrel was finally synthesized from 2-chlorobenzyl cyanide via bromination, condensation, hydrolyze, esterification, resolution, Finally with the sulfate, re-crystallization product of the target compound clopidogrel. The overall yield is 16%. Synthesis of the intermediate product and finally the structure of the product through ESI and1H-NMR corroboration. The improved synthetic procedure has the advantage of low cost and is suitable for industrial production.