Rod-shaped microglia morphology is associated with aging in 2 human autopsy series

NEUROBIOLOGY OF AGING

卷:52

Article

Bachstetter, Adam D.^1,2  Ighodaro, Eseosa T.^1,3  Hassoun, Yasmin¹  Aldeiri, Danah¹  Neltner, Janna H.^3,4  Patel, Ela³  Abner, Erin L.^3,5  Nelson, Peter T.^3,4 

[1] Univ Kentucky, Spinal Cord & Brain Injury Res Ctr, Lexington, KY USA

[2] Univ Kentucky, Dept Neurosci, Lexington, KY USA

[3] Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA

[4] Univ Kentucky, Dept Pathol & Lab Med, Div Neuropathol, Lexington, KY USA

[5] Univ Kentucky, Dept Epidemiol, Lexington, KY USA

关键词: Aging;    Microglia activation;    Neurodegeneration;    Neuroinflammation;    Neuropathology;    Hippocampus;    Alzheimer's disease;    Traumatic brain injury;   

DOI  :  10.1016/j.neurobiolaging.2016.12.028

来源: Elsevier

【 摘 要 】

A subtype of microglia is defined by the morphological appearance of the cells as rod shaped. Little is known about this intriguing cell type, as there are only a few case reports describing rod-shaped microglia in the neuropathological literature. Rod-shaped microglia were shown recently to account for a substantial proportion of the microglia cells in the hippocampus of both demented and cognitively intact aged individuals. We hypothesized that aging could be a defining feature in the occurrence of rodshaped microglia. To test this hypothesis, 2 independent series of autopsy cases (total n 168 cases), which covered the adult lifespan from 20 to 100_ years old, were included in the study. The presence or absence of rod-shaped microglia was scored on IBA1 immunohistochemically stained slides for the hippocampus and cortex. We found that age was one of the strongest determinants for the presence of rod-shaped microglia in the hippocampus and the cortex. We found no association with the presence of rod-shaped microglia and a self-reported history of a TBI. Alzheimer's diseaseerelated pathology was found to influence the presence of rod-shaped microglia, but only in the parietal cortex and not in the hippocampus or temporal cortex. Future studies are warranted to determine the functional relevance of rod-shaped microglia in supporting the health of neurons in the aged brain, and the signaling processes that regulate the formation of rod-shaped microglia. (C) 2017 Elsevier Inc. All rights reserved.

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