Novel targets for positron emission tomography (PET) radiopharmaceutical tracers for visualization of neuroinflammation

3rd International Conference and Young Scientist School "Magnetic resonance imaging in biomedical research"

物理学;医药卫生

Shchepetkin, I.^1,2 ; Shvedova, M.^2,3 ; Anfinogenova, Y.^2,4 ; Litvak, M.^2,4,5 ; Atochin, D.^2,5,6

Department of Microbiology and Immunology, Montana State University, Bozeman, Montana, United States^1

RASA Center in Tomsk, Tomsk Polytechnic University, Tomsk, Russia^2

Siberian State Medical University, Tomsk, Russia^3

Research Institute for Cardiology, Tomsk NRMC, Tomsk, Russia^4

Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Charlestown

MA, United States^5

Research Institute of Biology and Biophysics, Tomsk State University, Tomsk, Russia^6

关键词: Based on detections;    Functional information;    Imaging modality;    Neuroinflammation;    Neurological disease;    PET imaging;    Positron emission tomography (PET);    Positron emission tomography radiopharmaceuticals;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/886/1/012015/pdf
DOI  :  10.1088/1742-6596/886/1/012015

学科分类：卫生学

来源: IOP

【 摘 要 】

Non-invasive molecular imaging techniques can enhance diagnosis of neurological diseases to achieve their successful treatment. Positron emission tomography (PET) imaging can identify activated microglia and provide detailed functional information based on molecular biology. This imaging modality is based on detection of isotope labeled tracers, which emit positrons. The review summarizes the developments of various radiolabeled ligands for PET imaging of neuroinflammation.