Estimates of age-dependent cutoffs for pathological brain volume loss using SIENA/FSL-a longitudinal brain volumetry study in healthy adults

NEUROBIOLOGY OF AGING

卷:65

Article

Opfer, Roland^1,2,3  Ostwaldt, Ann-Christin³  Sormani, Maria Pia⁴  Gocke, Carola⁵  Walker-Egger, Christine^1,2  Manogaran, Praveena^1,2,6  De Stefano, Nicola⁷  Schippling, Sven^1,2 

[1] Univ Hosp Zurich, Neuroimmunol & Multiple Sclerosis Res, Dept Neurol, Zurich, Switzerland

[2] Univ Zurich, Zurich, Switzerland

[3] Jung Diagnost GmbH, Rontgenstr 24, D-22335 Hamburg, Germany

[4] Univ Genoa, Dept Hlth Sci, Biostat Unit, Genoa, Italy

[5] MPCH, Hamburg, Germany

[6] Swiss Fed Inst Technol, Dept Informat Technol & Elect Engn, Zurich, Switzerland

[7] Univ Siena, Dept Med Surg & Neurosci, Siena, Italy

关键词: Brain atrophy;    Aging;    Multiple sclerosis;    Brain volume loss;    SIENA;    Cutoff;   

DOI  :  10.1016/j.neurobiolaging.2017.12.024

来源: Elsevier

【 摘 要 】

Brain volume loss (BVL) has gained increasing interest for monitoring tissue damage in neurodegenerative diseases including multiple sclerosis (MS). In this longitudinal study, 117 healthy participants (age range 37.3-82.6 years) received at least 2 magnetic resonance imaging examinations. BVL (in %) was determined with the Structural Image Evaluation using Normalisation of Atrophy/FMRIB Software Library and annualized. Mean BVL per year was 0.15%, 0.30%, 0.46%, and 0.61% at ages 45, 55, 65, and 75 years, respectively. The corresponding BVL per year values of the age-dependent 95th percentiles were 0.52%, 0.77%, 1.05% and 1.45%. Pathological BVL can be assumed if an individual BVL per year exceeds these thresholds for a given age. The mean BVL per year determined in this longitudinal study was consistent with results from a cross-sectional study that was published recently. The cut-off for a pathological BVL per year at the age of 45 years (0.52%) was consistent with the cut-off suggested previously to distinguish between physiological and pathological BVL in MS patients. Different cut-off values, however, need to be considered when interpreting BVL assessed in cohorts of higher ages. (C) 2017 Elsevier Inc. All rights reserved.

【 授权许可】

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