Clinical trial methodologies for disease-modifying therapeutic approaches

NEUROBIOLOGY OF AGING

卷:32

Article

Aisen, Paul S.

关键词: Alzheimer's disease;    Biomarkers;    Clinical trials;   

DOI  :  10.1016/j.neurobiolaging.2011.09.008

来源: Elsevier

【 摘 要 】

In recent years, advances in Alzheimer's disease (AD) biomarker research have provided powerful tools to improve trial design. In particular, biomarkers provide powerful methods for the selection of individuals with Alzheimer's disease prior to the onset of dementia. Data suggest that neuroimaging biomarkers will be useful as endpoints for trials in very early, even asymptomatic disease, though further work is necessary to establish validity for regulatory purposes. (C) 2011 Elsevier Inc. All rights reserved.

【 授权许可】

Free